Description

Probarbital Calcium Salt Trihydrate is a pharmaceutical-grade barbiturate derivative, specifically formulated as a calcium salt with three water molecules of hydration. This compound is valued for its precise chemical composition and stability, making it a critical intermediate in the synthesis of specialized active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development and production of sedative-hypnotic agents and related therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of barbiturate-based active pharmaceutical ingredients (APIs).
• Chemical Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing.
• Research & Development: Serves as a precursor in medicinal chemistry research for developing new central nervous system (CNS) agents.
• Controlled Substance Synthesis: Employed in the licensed production of specific sedative and anesthetic compounds.

Basic Information

Product Name	Probarbital Calcium Salt Trihydrate
CAS No.	6193-02-8
Molecular Formula	C14H18CaN2O6 • 3H2O
Molecular Weight	404.42 g/mol (Anhydrous basis: 350.39 g/mol)
Synonyms	Calcium Probarbital Trihydrate; 5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione Calcium Salt Trihydrate; 5-Ethyl-5-sec-butylbarbituric Acid Calcium Salt Trihydrate; Calcium 5-Ethyl-5-(1-methylpropyl)barbiturate Trihydrate; Probarbital Calcium; NSC 401564
EINECS	Contact for details

Quality Control

Our Probarbital Calcium Salt Trihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	12.0% - 14.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.