Description

4-Methylestradiol is a synthetic estrogen derivative, a methylated analog of the natural hormone estradiol. This modification enhances its metabolic stability and potency, making it a compound of significant interest in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in endocrinology, oncology, and the development of novel hormone therapies.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of novel steroidal drugs and hormone replacement therapies.
• Endocrinology Studies: Used as a potent estrogenic agent in preclinical research to investigate estrogen receptor (ER) signaling pathways and related biological mechanisms.
• Oncology Research: Employed in studies exploring the role of estrogens and their analogs in hormone-dependent cancers, such as certain breast and prostate cancers.
• Biochemical Assay Development: Serves as a high-purity standard for calibrating analytical instruments (e.g., HPLC, LC-MS) in bioanalytical and quality control laboratories.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in steroid chemistry, pharmacology, and molecular biology.

Basic Information

Product Name	4-Methylestradiol
CAS No.	6171-48-8
Molecular Formula	C19H26O2
Molecular Weight	286.41 g/mol
Synonyms	4-ME2; 4-Methylestra-1,3,5(10)-triene-3,17β-diol; 17β-Hydroxy-4-methylestra-1,3,5(10)-trien-3-ol; 4-Methyl-17β-estradiol; 4-Methyl-E2
EINECS	Contact for details

Quality Control

Our 4-Methylestradiol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.