Description

Dl-Valine tert-Butyl Ester CAS NO 6070-59-3 is a protected amino acid derivative, specifically the tert-butyl ester of DL-valine, serving as a crucial chiral building block in organic synthesis. Its primary value lies in providing a versatile intermediate for the construction of complex peptides and active pharmaceutical ingredients (APIs) while offering enhanced solubility and stability during synthetic sequences. This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries engaged in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected valine residue.
• Asymmetric Synthesis: Employed in the preparation of non-natural amino acids and complex chiral compounds for medicinal chemistry research.
• Chemical Biology Research: Utilized in the development of peptide mimetics, enzyme substrates, and molecular probes.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals, flavors, and fragrances.
• Academic & Industrial R&D: Serves as a standard reagent in laboratories for method development and scale-up studies.

Basic Information

Product Name	Dl-Valine tert-Butyl Ester
CAS No.	6070-59-3
Molecular Formula	C9H19NO2
Molecular Weight	173.25 g/mol
Synonyms	DL-Valine tert-butyl ester; tert-Butyl DL-valinate; 2-Amino-3-methylbutanoic acid 1,1-dimethylethyl ester; Valine, tert-butyl ester, DL-; Butanoic acid, 2-amino-3-methyl-, 1,1-dimethylethyl ester; Boc-Val-OH (common misnomer, correct for Boc-protected); Val-OtBu; DL-Val-OtBu
EINECS	Contact for details

Quality Control

Our Dl-Valine tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	DL-mixture (typically ~50:50)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.