Description

Ethyl 4-Bromocrotonate is a versatile brominated ester building block, primarily valued for its role as a key intermediate in advanced organic synthesis. Its reactive bromine and activated alkene functionalities make it an essential reagent for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the production of active pharmaceutical ingredients (APIs), especially for molecules containing functionalized butenoate structures.
• Agrochemical Synthesis: Used in the research and manufacturing of advanced pesticides and herbicides, leveraging its reactivity to introduce bromine and ester groups.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and functional materials with tailored properties.
• Cross-Coupling Reactions: Acts as an effective electrophile in palladium-catalyzed reactions like Heck, Suzuki, and Negishi couplings for C-C bond formation.
• Organic Synthesis Building Block: Employed in Diels-Alder reactions and Michael additions to create complex, multi-functional organic molecules in R&D settings.
• Ligand and Catalyst Development: Utilized in the synthesis of novel ligands and organometallic complexes for catalytic applications.

Basic Information

Product Name	Ethyl 4-Bromocrotonate
CAS No.	6065-32-3
Molecular Formula	C6H9BrO2
Molecular Weight	193.04 g/mol
Synonyms	Ethyl (E)-4-Bromocrotonate; (E)-Ethyl 4-Bromobut-2-enoate; 4-Bromocrotonic Acid Ethyl Ester; 2-Butenoic acid, 4-bromo-, ethyl ester, (E)-; trans-Ethyl 4-bromocrotonate; Ethyl trans-4-bromocrotonate; NSC 3348; Ethyl γ-bromocrotonate
EINECS	227-984-2

Quality Control

Our Ethyl 4-Bromocrotonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Isomeric Purity (E/Z ratio)	≥ 95:5 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.