Description

Diethyl Fluoromalonate is a versatile fluorinated building block essential for advanced organic synthesis. Its value lies in the introduction of a fluorine atom and a reactive malonate ester moiety, enabling the construction of complex molecules with tailored properties. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, where the fluorine atom can enhance metabolic stability and bioavailability.
• Fluorine Chemistry Research: A fundamental reagent for studying nucleophilic fluorination reactions and developing new fluorination methodologies.
• Material Science: Building block for synthesizing fluorinated polymers, liquid crystals, and specialty materials with unique electronic or surface properties.
• Peptide Mimetics: Employed in the design and synthesis of fluorinated peptidomimetics to improve peptide stability and biological activity.

Basic Information

Product Name	Diethyl Fluoromalonate
CAS No.	685-88-1
Molecular Formula	C7H11FO4
Molecular Weight	178.16 g/mol
Synonyms	Fluoromalonic Acid Diethyl Ester; Diethyl 2-Fluoromalonate; Ethyl Fluoromalonate; Diethyl Fluoropropanedioate; 2-Fluoromalonic Acid Diethyl Ester; Propanedioic Acid, 2-Fluoro-, 1,3-Diethyl Ester; Malonic Acid, Fluoro-, Diethyl Ester
EINECS	211-694-8

Quality Control

Our Diethyl Fluoromalonate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.