Description

Diethyl 2,2-Difluoromalonate is a high-value fluorinated building block essential for introducing the difluoromethylene (CF2) group into complex molecular architectures. This compound matters because it enables precise synthesis in advanced pharmaceutical and agrochemical research, offering a versatile handle for constructing bioactive molecules with enhanced metabolic stability and lipophilicity. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications ranging from active pharmaceutical ingredient (API) synthesis to the development of novel fluorinated polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated analogs of drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine substitution improves efficacy and environmental persistence.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and coatings with unique chemical resistance and surface properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to incorporate the difluoromethylene unit into complex organic molecules.
• Ligand and Catalyst Development: Useful for creating fluorinated ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference compound or a synthetic precursor for molecules used in 19F NMR studies.

Basic Information

Product Name	Diethyl 2,2-Difluoromalonate
CAS No.	680-65-9
Molecular Formula	C7H10F2O4
Molecular Weight	196.15 g/mol
Synonyms	Diethyl difluoromalonate; 2,2-Difluoromalonic Acid Diethyl Ester; Ethyl 2,2-Difluoromalonate; Difluoromalonic Acid Diethyl Ester; Diethyl 2,2-Difluoropropanedioate; Diethyl Difluorobutanedioate; Malonic Acid, 2,2-Difluoro-, Diethyl Ester; Propanedioic Acid, 2,2-Difluoro-, Diethyl Ester
EINECS	211-673-4

Quality Control

Our Diethyl 2,2-Difluoromalonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.390 - 1.400
Density (20°C)	1.22 - 1.28 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.