Description

4-Nitrophenyl Trifluoroacetate is a specialized chemical reagent primarily used as an activated ester for the synthesis of amides and peptides. This compound matters for its role as a high-quality acylating agent, offering excellent reactivity and selectivity in coupling reactions under mild conditions. It is needed by research scientists and process chemists in the pharmaceutical, agrochemical, and biotechnology industries for the development of active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Peptide Synthesis: Employed as an activated ester for the acylation of amino groups in solid-phase and solution-phase peptide coupling.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of amide-containing drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used for labeling biomolecules, such as proteins and antibodies, with fluorophores or other functional groups via amine-reactive chemistry.
• Agrochemical Research: Applied in the development of novel herbicides, fungicides, and insecticides that require amide bond formation.
• Material Science: Utilized in the surface modification of polymers and the creation of functionalized materials through amidation reactions.
• Organic Synthesis: Acts as a versatile reagent for introducing the trifluoroacetyl group or for protecting group chemistry in multi-step synthetic routes.

Basic Information

Product Name	4-Nitrophenyl Trifluoroacetate
CAS No.	658-78-6
Molecular Formula	C8H4F3NO4
Molecular Weight	235.12 g/mol
Synonyms	p-Nitrophenyl Trifluoroacetate; Trifluoroacetic Acid 4-Nitrophenyl Ester; 4-Nitrophenyl Trifluoroethanoate; 2,2,2-Trifluoroacetic Acid 4-Nitrophenyl Ester; 4-Nitrophenyl Perfluoroacetate; 4-Nitrophenol Trifluoroacetate; NSC 404087; 4-Nitrophenyl Ester of Trifluoroacetic Acid
EINECS	211-525-6

Quality Control

Our 4-Nitrophenyl Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	62 - 66 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.