Description

Ethyl 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyrate is a versatile fluorinated building block prized for its unique trifluoromethyl and hydroxyl functionalities. This compound is critical for introducing the metabolically stable trifluoromethyl group into target molecules, significantly enhancing their lipophilicity and biological activity. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drugs, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the CF3 group improves efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies.
• Advanced Polymer Modification: Incorporates fluorine into polymer chains to alter surface properties, chemical resistance, and durability.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in asymmetric synthesis and cross-coupling reactions for complex molecule construction.
• Flavor & Fragrance Ingredient Intermediate: Used in the synthesis of specialty esters with unique organoleptic properties.

Basic Information

Product Name	Ethyl 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyrate
CAS No.	649-56-9
Molecular Formula	C7H11F3O3
Molecular Weight	200.16 g/mol
Synonyms	Ethyl 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutanoate; 4,4,4-Trifluoro-3-hydroxy-3-methylbutyric Acid Ethyl Ester; 3-Hydroxy-3-methyl-4,4,4-trifluorobutyric Acid Ethyl Ester; 3-Methyl-3-hydroxy-4,4,4-trifluorobutanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoro-3-hydroxy-3-methylbutyrate; 649-56-9; Butyric acid, 3-hydroxy-3-methyl-4,4,4-trifluoro-, ethyl ester
EINECS	211-473-9

Quality Control

Our Ethyl 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyrate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature and sensitivity to fluoride/strong alkali, keep away from heat, open flames, and incompatible materials. Keep container tightly sealed when not in use to prevent evaporation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.380 - 1.390
Specific Gravity (20°C)	1.220 - 1.280

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.