Description

Folinic Acid-Sf is a high-purity, biologically active form of folate (vitamin B9) essential for critical biochemical pathways. This compound is valued for its role as a rescue agent and metabolic modulator in high-value pharmaceutical and nutraceutical formulations. It is primarily required by manufacturers in the pharmaceutical, biotechnology, and advanced nutrition sectors for producing oncology drugs, parenteral nutrition solutions, and high-end dietary supplements.

Application

• Oncology Support Therapy: As a rescue agent to mitigate the toxicity of methotrexate and other folate antagonist chemotherapeutics.
• Parenteral Nutrition: A key ingredient in intravenous vitamin formulations for patients with malabsorption or increased metabolic demands.
• Advanced Nutraceuticals: Used in premium dietary supplements targeting cellular health, methylation support, and cognitive function.
• Biochemical Research: Serves as a critical reagent in cell culture media and enzymatic studies involving folate-dependent pathways.
• Pharmaceutical Synthesis: An active pharmaceutical ingredient (API) and intermediate in the production of specialized folate-based medications.
• Veterinary Medicine: Incorporated into therapeutic feeds and injectables for livestock and companion animals.

Basic Information

Product Name	Folinic Acid-Sf
CAS No.	641-41-8
Molecular Formula	C20H23N7O7
Molecular Weight	473.44 g/mol
Synonyms	Leucovorin; 5-Formyltetrahydrofolate; Citrovorum Factor; 5-CHO-THF; Calcium Folinate; (6S)-5-Formyltetrahydrofolic Acid; (6S)-5-Formyl-5,6,7,8-tetrahydrofolic Acid; Antifolate Rescue Agent
EINECS	211-400-6

Quality Control

Our Folinic Acid-Sf is manufactured under strict quality management systems, with specifications designed to meet the rigorous demands of pharmaceutical applications. Each batch is tested for identity, purity, and potency using validated analytical methods, including HPLC and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing compliance with relevant in-house or pharmacopeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+14.0° to +20.0° (c=1 in 0.1N NaOH)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.