Description

Chlorguanide Hydrochloride is a synthetic organic compound belonging to the biguanide class, widely recognized for its role as a key pharmaceutical intermediate. Its primary commercial value lies in its use as a precursor in the synthesis of antimalarial drugs, most notably proguanil. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries who require a reliable, high-purity building block for active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: Primary use as a key precursor in the synthesis of the antimalarial drug Proguanil.
• Antimalarial Drug Production: Serves as the core chemical entity for manufacturing APIs used in malaria prophylaxis and treatment formulations.
• Fine Chemical Synthesis: Utilized in research and development for creating novel biguanide derivatives with potential therapeutic applications.
• Biochemical Research: Employed in studies investigating the mechanism of action of antifolate agents and parasite biochemistry.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug testing and verification.

Basic Information

Product Name	Chlorguanide Hydrochloride
CAS No.	637-32-1
Molecular Formula	C11H16ClN5•HCl
Molecular Weight	290.19 g/mol
Synonyms	Proguanil Impurity A; Chloroguanide Hydrochloride; 1-(4-Chlorophenyl)-5-isopropylbiguanide Hydrochloride; Paludrine Impurity A; N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride; Bigumalum; Chlorguanidi Hydrochloridum; NSC-3061
EINECS	211-286-5

Quality Control

Our Chlorguanide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications suitable for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing the results for each parameter is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.