Description

Pamaquine is an 8-aminoquinoline derivative with significant historical and research importance in the field of antimalarial chemotherapy. Its primary value lies in its unique activity against the dormant hypnozoite stage of *Plasmodium vivax* and *Plasmodium ovale* parasites, which is critical for achieving radical cure and preventing relapses. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and manufacturers focused on developing and synthesizing advanced antiprotozoal agents and studying structure-activity relationships in medicinal chemistry.

Application

• Antimalarial Drug Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the study and synthesis of 8-aminoquinoline-based therapeutics.
• Pharmacological Studies: Used in vitro and in vivo to investigate mechanisms of action, efficacy, and toxicity profiles of primaquine-like compounds.
• Medicinal Chemistry Synthesis: Serves as a crucial building block or precursor for the chemical modification and creation of novel analogs with improved therapeutic indices.
• Academic & Clinical Reference: Employed as a certified reference material (CRM) in university laboratories and clinical research settings for method development and validation.
• Pharmaceutical Manufacturing: Used as an intermediate in the controlled production of specialty antimalarial agents under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	Pamaquine
CAS No.	635-05-2
Molecular Formula	C₁₉H₂₉N₃O
Molecular Weight	315.45 g/mol
Synonyms	Pamachin; Plasmoquine; Aminoquin; Gamefar; 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline; N1,N1-Diethyl-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine; SN 971
EINECS	211-235-8

Quality Control

Our Pamaquine is manufactured and tested to meet high-purity standards suitable for research and development applications. Each batch undergoes rigorous analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, assay, purity, and related substances is provided to ensure traceability and quality assurance for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.