Description

Ethyl 2-Benzylacetoacetate is a versatile β-keto ester derivative, serving as a critical building block in organic synthesis. Its value lies in its bifunctional reactivity, enabling the construction of complex heterocyclic and pharmaceutical intermediates. This compound is essential for R&D chemists and production facilities in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-purity synthetic precursors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing heterocyclic structures like pyrazoles and pyridines.
• Agrochemical Synthesis: Used in the manufacturing of pesticides, herbicides, and fungicides, where its acetoacetate moiety is utilized for ring formation.
• Fine Chemical Production: Serves as a starting material for dyes, pigments, and specialty chemicals requiring specific ketone and ester functionalities.
• Flavor and Fragrance Ingredient: Employed in the synthesis of aroma compounds, leveraging its ability to form fruity and floral notes upon chemical modification.
• Academic and Industrial Research: A valuable reagent for methodological development in organic chemistry, including studies on Claisen condensations and Michael additions.
• Coordination Chemistry: Acts as a ligand or precursor for metal-organic frameworks (MOFs) and catalysts due to its chelating β-keto ester group.

Basic Information

Product Name	Ethyl 2-Benzylacetoacetate
CAS No.	620-79-1
Molecular Formula	C13H16O3
Molecular Weight	220.26 g/mol
Synonyms	Ethyl 2-Benzyl-3-oxobutanoate; 2-Benzylacetoacetic Acid Ethyl Ester; Ethyl Benzylacetoacetate; Acetoacetic Acid, 2-Benzyl-, Ethyl Ester; Ethyl (Benzylacetyl)acetate; 3-Oxobutanoic Acid, 2-(Phenylmethyl)-, Ethyl Ester; Ethyl α-Benzylacetoacetate; NSC 404080
EINECS	210-660-4

Quality Control

Our Ethyl 2-Benzylacetoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC for residual solvents, to ensure it meets exacting standards for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Refractive Index (20°C)	1.508 - 1.512
Density (20°C)	1.08 - 1.12 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.