Description

Dicethiamine Hydrochloride is a synthetic thiamine (vitamin B1) derivative, specifically the diethyl ester of thiamine hydrochloride. This compound is valued for its enhanced lipophilicity compared to thiamine, which can improve its absorption and bioavailability in certain formulations. It serves as a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of specialized pharmaceutical products. Dicethiamine Hydrochloride CAS NO 616-96-6 is primarily utilized by manufacturers in the pharmaceutical and nutraceutical industries for the development of vitamin supplements and therapeutic agents targeting thiamine deficiency.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of prescription and over-the-counter medications for treating and preventing vitamin B1 deficiency.
• Nutraceutical and Dietary Supplements: Incorporated into high-potency vitamin B-complex supplements and specialized nutritional products.
• Veterinary Pharmaceuticals: Applied in animal health products for livestock and companion animals to ensure adequate thiamine levels.
• Research and Development: Serves as a key intermediate or reference standard in pharmaceutical R&D for studying thiamine metabolism and developing new derivatives.
• Cosmeceutical Formulations: Explored in advanced skincare products for its potential antioxidant and cellular energy-boosting properties.

Basic Information

Product Name	Dicethiamine Hydrochloride
CAS No.	616-96-6
Molecular Formula	C₁₄H₂₃ClN₄O₂S
Molecular Weight	346.87 g/mol
Synonyms	Diethyl Thiamine Hydrochloride; Thiamine Diethyl Ester Hydrochloride; Dicethiamine HCl; O,O-Diethyl Thiamine Hydrochloride; Vitamin B1 Diethyl Ester Hydrochloride; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride Diethyl Ester; Benerva Diethyl Ester Hydrochloride (historical)
EINECS	210-506-8

Quality Control

Our Dicethiamine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide detailed Certificates of Analysis (COA) that include identity confirmation, assay, impurity profile, and residual solvent analysis. Our quality commitment aligns with cGMP (Current Good Manufacturing Practice) guidelines, and we can support documentation for regulatory submissions in global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solubility	Freely soluble in water, soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.