Description

(8Alpha,9R)-10,11-Dihydro-6'-[(6-Methylheptyl)Oxy]Cinchonan-9-Ol Dihydrochloride is a high-purity, synthetic derivative of cinchona alkaloids, valued for its role as a versatile chiral intermediate and ligand in asymmetric synthesis. This compound is critical for enabling precise stereochemical control in the production of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing enantiomerically pure products.

Application

• As a chiral ligand or catalyst in asymmetric hydrogenation, dihydroxylation, and other transition metal-catalyzed reactions.
• A key intermediate in pharmaceutical research for the synthesis of novel therapeutic agents, particularly those targeting malaria and cardiac conditions.
• Use in the development and scale-up of enantioselective processes for the production of agrochemicals and flavors & fragrances.
• As a reference standard in analytical chemistry for method development and quality control in chiral separations.
• Employed in academic and industrial R&D for studying reaction mechanisms and exploring new catalytic systems.

Basic Information

Product Name	(8Alpha,9R)-10,11-Dihydro-6'-[(6-Methylheptyl)Oxy]Cinchonan-9-Ol Dihydrochloride
CAS No.	605-08-3
Molecular Formula	C₂₀H₃₀N₂O₂·2HCl
Molecular Weight	407.38 g/mol (Free base)
Synonyms	Dihydroquinidine 6'-Methyl Ether Dihydrochloride; (8α,9R)-10,11-Dihydro-6'-[(6-methylheptyl)oxy]cinchonan-9-ol dihydrochloride; 6'-O-Methyldihydroquinidine Dihydrochloride; Dihydroquinidine Methyl Ether Dihydrochloride; DHQD-MEQ Dihydrochloride; Cinchonan-9-ol, 10,11-dihydro-6'-[(6-methylheptyl)oxy]-, (8α,9R)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our (8Alpha,9R)-10,11-Dihydro-6'-[(6-Methylheptyl)Oxy]Cinchonan-9-Ol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets exacting standards for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.