Description

(R)-Phenylephrine Hydrochloride is the pharmacologically active enantiomer of the α-1 adrenergic receptor agonist phenylephrine. This high-purity chiral compound is critical for applications requiring stereochemical specificity and minimal side-effect profiles. It is primarily utilized by the pharmaceutical industry for the research, development, and manufacturing of enantiomerically pure nasal decongestants, ophthalmic solutions, and cardiovascular medications.

Application

• Pharmaceutical Active Ingredient (API): Core component in prescription and over-the-counter (OTC) nasal decongestant sprays and drops.
• Ophthalmic Solutions: Used in eye drops to induce mydriasis (pupil dilation) for diagnostic procedures and surgeries.
• Cardiovascular Research: A standard agent in pharmacological studies of vasoconstriction and blood pressure regulation.
• Chiral Intermediate: Serves as a key building block in the synthesis of more complex enantiopure pharmaceutical compounds.
• Analytical Reference Standard: High-purity material for quality control (QC) and assay development in pharmaceutical laboratories.
• Veterinary Medicine: Employed in formulations for treating hypotension and nasal congestion in animals.

Basic Information

Product Name	(R)-Phenylephrine Hydrochloride
CAS No.	61-76-7
Molecular Formula	C9H14ClNO2 • HCl
Molecular Weight	203.67 g/mol (Free base: 167.21 g/mol)
Synonyms	(R)-(-)-Phenylephrine Hydrochloride; L-Phenylephrine Hydrochloride; (-)-Phenylephrine HCl; (R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol Hydrochloride; Metasympatol; Neo-Synephrine (enantiomer); Mydfrin (active enantiomer); Adrenalone congener
EINECS	200-515-2

Quality Control

Our (R)-Phenylephrine Hydrochloride is manufactured under strict quality management systems. It is typically produced to meet or exceed relevant pharmacopoeial standards such as USP and EP for pharmaceutical applications. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles to ensure batch-to-batch consistency and regulatory compliance for GMP-driven applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R)-isomer
Water (KF Titration)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.