Description

Quinine Dihydrochloride is a vital pharmaceutical salt of the naturally occurring alkaloid quinine. It serves as a key analytical standard and active pharmaceutical ingredient (API) in the development and quality control of antimalarial medications. This compound is essential for manufacturers and research institutions in the pharmaceutical, analytical chemistry, and life science sectors requiring high-purity reference materials.

Application

• Pharmaceutical API: Used as an active ingredient in the formulation of antimalarial drugs and other therapeutic agents.
• Analytical Reference Standard: Serves as a primary standard in High-Performance Liquid Chromatography (HPLC), spectroscopy, and titration for quality control and research.
• Biochemical Research: Employed in pharmacological studies to investigate its effects on muscle contraction, cardiac function, and parasitic diseases.
• Beverage Industry (Analytical): Used as a calibration standard for the quantification of quinine in tonic waters and other bittering agents.
• Chemical Synthesis: Acts as a chiral starting material or intermediate in the synthesis of more complex pharmaceutical compounds.

Basic Information

Item	Detail
Product Name	Quinine Dihydrochloride
CAS No.	60-93-5
Molecular Formula	C20H24N2O2 · 2HCl
Molecular Weight	397.34 g/mol (as dihydrochloride salt)
Synonyms	Quinine Hydrochloride Dihydrate; Quinine Dihydrochloride Dihydrate; Quinine HCl; (8S,9R)-6'-Methoxycinchonan-9-ol Dihydrochloride; Cinchonan-9-ol, 6'-methoxy-, dihydrochloride, (8α,9R)-; NSC 177384; Quinine Chloride; China alkaloid dihydrochloride
EINECS	200-495-7

Quality Control

Our Quinine Dihydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including HPLC for purity, identification by IR spectroscopy, and tests for specific rotation, loss on drying, and residue on ignition to ensure it meets high-grade standards suitable for pharmaceutical and analytical applications. A Certificate of Analysis (COA) is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	-223° to -229° (c=2 in 0.1M HCl)
Loss on Drying	≤ 3.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.