Description

Phlorizin is a natural dihydrochalcone glucoside and a potent, specific inhibitor of the sodium-glucose linked transporter (SGLT) family. This unique mechanism of action makes it a critical reference standard and research tool in the study of glucose metabolism, diabetes, and renal function. It is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and life science industries.

Application

• Pharmaceutical Research & Development: A key reference standard for studying SGLT1 and SGLT2 inhibition, crucial for developing novel anti-diabetic and anti-obesity therapeutics.
• Biochemical Assay Development: Used as a positive control and inhibitor in in vitro assays to validate screening platforms for glucose transport activity.
• Metabolic Disorder Studies: Fundamental research tool for investigating renal glucose reabsorption, intestinal sugar absorption, and their roles in metabolic syndrome.
• Natural Product & Nutraceutical Analysis: Serves as a marker compound for the standardization and quality control of botanical extracts, particularly from apple tree bark.
• Academic & Clinical Research: Employed in preclinical studies to elucidate the physiological and pathophysiological roles of SGLT proteins.

Basic Information

Product Name	Phlorizin
CAS No.	60-81-1
Molecular Formula	C21H24O10
Molecular Weight	436.41 g/mol
Synonyms	Phloridzin; Phloretin 2'-β-D-glucoside; 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; NSC 407292; Floridzin; Apple peel extract constituent; SGLT inhibitor
EINECS	200-487-1

Quality Control

Our Phlorizin is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.