Description

2-Pyrrolidinecarbonitrile, 1-(Chloroacetyl)-4,4-Difluoro-, (2S)- (9Ci) is a high-value, chiral fluorinated pyrrolidine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in its unique stereochemistry and functional groups, which enable the construction of complex molecular architectures with high precision. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drug candidates, especially in protease inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its fluorinated pyrrolidine scaffold.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry, particularly in fluorination and cyclization reactions.
• Peptidomimetics: Used in the design and synthesis of peptidomimetic compounds for drug discovery programs.

Basic Information

Product Name	2-Pyrrolidinecarbonitrile, 1-(Chloroacetyl)-4,4-Difluoro-, (2S)- (9Ci)
CAS No.	596817-02-6
Molecular Formula	C7H7ClF2N2O
Molecular Weight	208.59 g/mol
Synonyms	(2S)-1-(Chloroacetyl)-4,4-difluoropyrrolidine-2-carbonitrile; 1-(Chloroacetyl)-4,4-difluoro-L-prolinenitrile; 4,4-Difluoro-1-(chloroacetyl)-L-prolinenitrile; (S)-1-(2-Chloroacetyl)-4,4-difluoropyrrolidine-2-carbonitrile; L-Prolinenitrile, 1-(chloroacetyl)-4,4-difluoro-; 1-Chloroacetyl-4,4-difluoro-(S)-prolinenitrile
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonitrile, 1-(Chloroacetyl)-4,4-Difluoro-, (2S)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.