Description

2(3H)-Furanone, Dihydro-3-(1-Oxo-3-Butynyl)-, (3R)- (9Ci) is a specialized chiral lactone derivative, a high-value intermediate in advanced organic synthesis. Its unique structure, featuring a fused furanone ring and an activated butynyl ketone moiety, makes it a critical building block for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides, where the (3R)- configuration can be crucial for biological activity.
• Fine Chemical Manufacturing: Serves as a versatile precursor for synthesizing complex natural product analogs, flavors, and fragrances requiring specific lactone frameworks.
• Academic & Industrial R&D: Employed in methodological chemistry research for developing new asymmetric synthesis routes and studying cycloaddition reactions.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or functional materials with tailored optical or electronic properties.

Basic Information

Product Name	2(3H)-Furanone, Dihydro-3-(1-Oxo-3-Butynyl)-, (3R)- (9Ci)
CAS No.	594837-98-6
Molecular Formula	C8H8O3
Molecular Weight	152.15 g/mol
Synonyms	(3R)-Dihydro-3-(1-oxo-3-butynyl)-2(3H)-furanone; (R)-3-(1-Oxo-3-butynyl)dihydro-2(3H)-furanone; (3R)-3-(1-Oxo-3-butynyl)dihydrofuran-2(3H)-one; (R)-3-(1-Oxo-3-butynyl)-2(3H)-furanone; 594837-98-6; (R)-3-(3-Butynoyl)dihydrofuran-2(3H)-one; Chiral butynyl furanone; (R)-enantiomer of 3-(1-oxo-3-butynyl)dihydro-2(3H)-furanone
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profile is provided with every shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (3R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.