Description

n-Boc-4-Bromo-L-Phenylalanine Ethyl Ester is a protected amino acid derivative that serves as a crucial chiral building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine group by the Boc (tert-butoxycarbonyl) moiety and the reactive bromine substituent on the aromatic ring, enabling selective and sequential chemical transformations. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide drugs, protease inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in medicinal chemistry for constructing non-natural amino acid residues to enhance the metabolic stability and bioavailability of peptide leads.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry: Serves as a valuable building block in solid-phase and solution-phase peptide synthesis for generating diverse compound libraries.
• Agrochemical Synthesis: Potential intermediate in the development of specialized herbicides or plant growth regulators containing modified amino acid structures.

Basic Information

Product Name	n-Boc-4-Bromo-L-Phenylalanine Ethyl Ester
CAS No.	591249-54-6
Molecular Formula	C₁₆H₂₂BrNO₄
Molecular Weight	372.26 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-bromophenyl)propanoic acid ethyl ester; Ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-bromophenyl)propanoate; Boc-4-Br-Phe-OEt; Boc-L-4-Bromophenylalanine ethyl ester; tert-Butyl (1S)-1-(ethoxycarbonyl)-2-(4-bromophenyl)ethylcarbamate; N-Boc-4-bromo-L-phenylalanine ethyl ester; N-(tert-Butoxycarbonyl)-4-bromo-L-phenylalanine ethyl ester; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-bromo-, ethyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-4-Bromo-L-Phenylalanine Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.