Description

2-Chloro-4-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive nicotinic acid scaffold with chloro and trifluoromethyl substituents, enabling precise molecular modifications. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored electronic properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Nicotinic Acid
CAS No.	590371-81-6
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-; 2-Chloro-4-trifluoromethylnicotinic acid; 590371-81-6; 2-Chloro-4-(trifluoromethyl)nicotinate; Nicotinic acid, 2-chloro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.