Description

2-Pyridinecarboxamide,n-(3R)-1-Azabicyclo[3.2.2]Non-3-Yl-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex bicyclic amine structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and receptor-targeted therapies. Pharmaceutical R&D departments and fine chemical manufacturers need this material to develop and scale up next-generation drug candidates, where precise stereochemistry and purity are paramount for biological activity.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel central nervous system (CNS) active drugs and receptor modulators.
• Neurological Research: Used in the development of preclinical candidates targeting nicotinic acetylcholine receptors (nAChRs) and related neurological pathways.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for GMP-scale API manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of complex molecules for clinical trials.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	2-Pyridinecarboxamide,n-(3R)-1-Azabicyclo[3.2.2]Non-3-Yl-(9Ci)
CAS No.	590371-80-5
Molecular Formula	C14H19N3O
Molecular Weight	245.32 g/mol
Synonyms	N-[(3R)-1-Azabicyclo[3.2.2]non-3-yl]pyridine-2-carboxamide; (R)-N-(1-Azabicyclo[3.2.2]non-3-yl)nicotinamide; 2-Pyridinecarboxamide, N-[(3R)-1-azabicyclo[3.2.2]non-3-yl]-; 590371-80-5; UNII-8V8Y7Q6Q3F; 8V8Y7Q6Q3F; (R)-N-(1-Azabicyclo[3.2.2]nonan-3-yl)picolinamide
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarboxamide,n-(3R)-1-Azabicyclo[3.2.2]Non-3-Yl-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.