Description

4-Iodo-2-(Trifluoromethyl)Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both iodine and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for introducing these functional motifs into target molecules. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the trifluoromethylpyridine scaffold.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to create complex biaryl and conjugated systems.
• Ligand and Catalyst Development: Employed in the preparation of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on the physicochemical and biological properties of heterocyclic compounds.

Basic Information

Product Name	4-Iodo-2-(Trifluoromethyl)Pyridine
CAS No.	590371-73-6
Molecular Formula	C6H3F3IN
Molecular Weight	272.99 g/mol
Synonyms	2-(Trifluoromethyl)-4-iodopyridine; 4-Iodo-2-trifluoromethylpyridine; 4-Iodo-2-(trifluoromethyl)pyridine; Pyridine, 4-iodo-2-(trifluoromethyl)-; 590371-73-6
EINECS	Contact for details

Quality Control

Our 4-Iodo-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.