Description

Imidazo[1,5-a]pyridine-6-carboxamide, N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]- is a sophisticated chiral building block and pharmaceutical intermediate of significant interest in modern organic synthesis. This compound matters for its role in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Asymmetric Synthesis: Employed in the construction of complex molecules requiring the specific stereochemistry provided by its (1S,2R,4R)-7-azabicyclo[2.2.1]heptane moiety.
• Chemical Biology Probes: Serves as a starting material for developing tool compounds and probes to study biological mechanisms.
• Process Chemistry Development: Used in scaling up synthetic routes for advanced intermediates under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Item	Detail
Product Name	Imidazo[1,5-a]pyridine-6-carboxamide, N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-
CAS No.	588726-46-9
Molecular Formula	C14H16N4O
Molecular Weight	256.31 g/mol
Synonyms	N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]imidazo[1,5-a]pyridine-6-carboxamide; (1S,2R,4R)-N-(Imidazo[1,5-a]pyridin-6-ylcarbonyl)-7-azabicyclo[2.2.1]heptan-2-amine; 7-Azabicyclo[2.2.1]heptane-2-carboxamide, N-imidazo[1,5-a]pyridin-6-yl-, (1S,2R,4R)-; Imidazo[1,5-a]pyridine-6-carboxylic acid, 2-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-ylamino]-2-oxoethyl ester (tautomer); 588726-46-9; Chiral Imidazopyridine Amide; Endo-Norcamphor Derived Amide Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical research and development. Every batch undergoes comprehensive analytical characterization, including Chiral HPLC to confirm enantiomeric excess and NMR for structural verification. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific client requirements or regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.