Description

n-tert-Butyl-2-Chloroisonicotinamide is a specialized organic compound belonging to the isonicotinamide class, serving as a crucial building block in advanced chemical synthesis. Its value lies in its unique molecular structure, which incorporates both a chloro-substituted pyridine ring and a sterically hindered tert-butyl amide group, making it a versatile intermediate for constructing complex molecules. This product is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require high-purity, structurally defined intermediates for drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development and optimization of new herbicides and fungicides, where the chloro and amide functionalities contribute to biological activity.
• Ligand and Catalyst Precursor: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Monomer: Can be utilized in the research of functional polymers and advanced materials requiring specific pyridine-based monomers.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Industrial R&D: Employed in research laboratories for methodological studies in heterocyclic and amide chemistry, as well as for creating compound libraries for high-throughput screening.

Basic Information

Product Name	n-tert-Butyl-2-Chloroisonicotinamide
CAS No.	588694-28-4
Molecular Formula	C10H13ClN2O
Molecular Weight	212.68 g/mol
Synonyms	2-Chloro-N-(tert-butyl)isonicotinamide; 2-Chloro-N-tert-butylisonicotinamide; 2-Chloro-N-(1,1-dimethylethyl)-4-pyridinecarboxamide; 4-Pyridinecarboxamide, 2-chloro-N-(1,1-dimethylethyl)-; N-(tert-Butyl)-2-chloroisonicotinamide; tert-Butyl 2-chloroisonicotinamide; 588694-28-4; AI3-63525
EINECS	Contact for details

Quality Control

Our n-tert-Butyl-2-Chloroisonicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced chemical intermediates. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results from tests including HPLC assay, related substances, and residual solvents. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.