Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-dimethylethyl) ester is a crucial protected intermediate in the synthesis of macrocyclic chelating agents. This compound matters because it serves as a key precursor for producing high-purity DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives, which are essential for creating advanced contrast agents in medical imaging. Pharmaceutical R&D laboratories, diagnostic imaging manufacturers, and radiopharmaceutical producers need this high-purity building block to develop next-generation MRI and nuclear medicine agents.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of DOTA and its metal complexes (e.g., Gadolinium(III), Lutetium-177, Yttrium-90 chelates).
• Contrast Agent Precursor: Critical in the manufacturing of macrocyclic MRI contrast agents (e.g., Gadoterate meglumine) due to its high kinetic and thermodynamic stability.
• Radiopharmaceuticals: Used to create chelators for therapeutic and diagnostic radiometals in targeted alpha therapy (TAT) and peptide receptor radionuclide therapy (PRRT).
• Research & Development: Employed in academic and industrial labs for developing new bifunctional chelators for antibody-drug conjugates (ADCs) and molecular imaging probes.
• Chemical Synthesis: Serves as a protected form of DOTA, allowing for selective functionalization and conjugation to biomolecules like peptides, antibodies, and small molecules.
• Quality Control Reference Standard: Can be utilized as a reference material in analytical methods (HPLC, MS) for quality assurance of final drug substances.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-dimethylethyl) ester
CAS No.	585531-74-4
Molecular Formula	C36H68N4O8
Molecular Weight	684.95 g/mol
Synonyms	DOTA-tris(t-Bu ester); DOTA-tris(tert-butyl ester); 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tris(tert-butyl) ester; DOTA-tBu ester; Cyclen tetraacetic acid tetrakis(tert-butyl) ester; Tetrakis(tert-butyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; 2,2',2''-(10-(1,1-Dimethylethoxy)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid 1,1-dimethylethyl ester; DOTA tris-tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-dimethylethyl) ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity (by HPLC/NMR), residual solvents, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.