Description

Tos-Peg5 T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a tosyl (Tos) leaving group and a terminal tert-butyl ester. This compound is a versatile bifunctional linker and building block critical for the controlled synthesis and modification of complex molecules. It is primarily used by researchers and manufacturers in the pharmaceutical and bioconjugation industries who require precise, reproducible, and scalable chemical intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutics.
• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or nanoparticles via its reactive tosyl group.
• Polymer Chemistry: Acts as a functional initiator or monomer for creating tailored PEG-based copolymers with specific end-group functionality.
• Proteomics Research: Employed in the modification and cross-linking of biomolecules for study and analysis.
• Material Science: Utilized in the surface functionalization of materials to impart hydrophilicity and biocompatibility.
• Click Chemistry Precursor: The tert-butyl ester can be deprotected to yield a carboxylic acid for further amide coupling or conjugation reactions.

Basic Information

Product Name	Tos-Peg5 T-Butyl Ester
CAS No.	581065-94-3
Molecular Formula	C24H40O9S
Molecular Weight	504.64 g/mol
Synonyms	2,5,8,11,14-Pentaoxaheptadecan-17-oic acid, 16-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester; tert-Butyl 16-((tosyloxy)hexaethylene glycol)acetate; Tos-PEG5-t-butyl ester; Tosyl-PEG5-t-butyl ester; α-Tosyl-ω-tert-butyl ester pentaethylene glycol; PEG5 Tosylate t-Butyl Ester; 1-tert-Butyl 16-(4-methylbenzenesulfonate) 3,6,9,12,15-pentaoxahexadecanedioate
EINECS	Contact for details

Quality Control

Our Tos-Peg5 T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.