Description

tert-Butyl ((2S,4S)-2-(Trifluoromethyl)Piperidin-4-Yl)Carbamate is a high-value, stereochemically defined chiral piperidine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, enantiomerically pure building blocks.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Research: Used as a building block for developing new, enantiomerically pure pesticides and herbicides with improved efficacy.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioactive Molecule Synthesis: The piperidine core and protected amine functionality make it valuable for creating peptide analogs and other bioactive compounds.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific stereochemistry and a trifluoromethyl group.
• Academic & R&D Laboratories: Employed in methodological research and the discovery of new synthetic pathways involving fluorinated compounds.

Basic Information

Product Name	tert-Butyl ((2S,4S)-2-(Trifluoromethyl)Piperidin-4-Yl)Carbamate
CAS No.	577692-49-0
Molecular Formula	C12H21F3N2O2
Molecular Weight	282.30 g/mol
Synonyms	Boc-4-amino-2-(trifluoromethyl)piperidine (S,S-isomer); (2S,4S)-4-[(tert-Butoxycarbonyl)amino]-2-(trifluoromethyl)piperidine; tert-Butyl N-[(3S,5S)-5-(trifluoromethyl)-3-piperidyl]carbamate; (S,S)-Boc-2-CF3-4-Aminopiperidine; Boc-(2S,4S)-2-CF3-4-Aminopiperidine; N-Boc-2-(trifluoromethyl)piperidin-4-amine (S,S); 1,1-Dimethylethyl N-[(3S,5S)-5-(trifluoromethyl)-3-piperidinyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl ((2S,4S)-2-(Trifluoromethyl)Piperidin-4-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity, chemical identity, and consistent potency, meeting the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, MS) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.