Description

5,7-Dioxaspiro[2.5]Octane-4,8-Dione,1-Ethyl-2,6,6-Trimethyl-,(1R,2S)-Rel-(9Ci) is a high-purity, stereochemically defined spirocyclic compound that serves as a sophisticated chiral building block in advanced organic synthesis. Its unique fused ring structure and defined stereochemistry make it a critical intermediate for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, stereoselective pesticides and herbicides where specific chirality impacts biological activity and environmental profile.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multistep synthesis of specialty chemicals, flavors, and fragrances requiring complex, rigid spirocyclic frameworks.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, enabling exploration of new spiroannulation and stereocontrol strategies.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with unique thermal and mechanical properties derived from its rigid spiro structure.

Basic Information

Item	Details
Product Name	5,7-Dioxaspiro[2.5]Octane-4,8-Dione,1-Ethyl-2,6,6-Trimethyl-,(1R,2S)-Rel-(9Ci)
CAS No.	575456-73-4
Molecular Formula	C11H16O4
Molecular Weight	212.24 g/mol
Synonyms	(1R,2S)-rel-1-Ethyl-2,6,6-trimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione; 1-Ethyl-2,6,6-trimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione, (1R,2S)-rel-; (rel)-(1R,2S)-1-Ethyl-2,6,6-trimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione; Spirocyclic 1,3-dioxane-4,6-dione derivative; Chiral spiro diketone; Ethyl-trimethyl-dioxaspirooctanedione
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including Chiral HPLC, NMR, and GC/MS to confirm identity, stereochemical purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.