Description

5-Amino-3-(trifluoromethyl)picolinonitrile is a high-value, multi-functional heterocyclic building block featuring a nitrile and an amino group on a pyridine core. This compound is essential for advanced research and development in medicinal chemistry, enabling the synthesis of novel, complex molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for creating active pharmaceutical ingredients (APIs) and agrochemical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing groups and coordination sites.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	5-Amino-3-(trifluoromethyl)picolinonitrile
CAS No.	573762-62-6
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	3-(Trifluoromethyl)-5-aminopicolinonitrile; 5-Amino-3-(trifluoromethyl)-2-pyridinecarbonitrile; 2-Cyano-5-amino-3-trifluoromethylpyridine; 5-Amino-3-trifluoromethylpyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-amino-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Amino-3-(trifluoromethyl)picolinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.