Description

4-Chloro-7-[3-(Trifluoromethyl)Pyridin-2-Yl]Quinazoline is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. Its molecular architecture, featuring a quinazoline core linked to a trifluoromethylpyridine moiety, makes it a critical precursor for the synthesis of targeted kinase inhibitors and other bioactive molecules. This compound is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protein kinase inhibitors, particularly in oncology research targeting EGFR, VEGFR, and other tyrosine kinases.
• Agrochemical Synthesis: Serves as a building block for creating novel active ingredients with potential herbicidal or fungicidal properties, leveraging the biological activity of the quinazoline scaffold.
• Chemical Biology & Proteomics: Used in the design and synthesis of chemical probes for studying enzyme function and signal transduction pathways.
• Material Science Research: Investigated as a precursor for organic electronic materials due to its conjugated π-system and electron-deficient character.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of candidate drugs under cGMP conditions.

Basic Information

Product Name	4-Chloro-7-[3-(Trifluoromethyl)Pyridin-2-Yl]Quinazoline
CAS No.	573675-83-9
Molecular Formula	C₁₄H₇ClF₃N₃
Molecular Weight	309.67 g/mol
Synonyms	4-Chloro-7-(3-(trifluoromethyl)pyridin-2-yl)quinazoline; 2-(4-Chloroquinazolin-7-yl)-3-(trifluoromethyl)pyridine; 4-Chloro-7-(3-trifluoromethyl-2-pyridinyl)quinazoline; 573675-83-9; 4-Chloro-7-(3-(trifluoromethyl)-2-pyridinyl)quinazoline; Quinazoline, 4-chloro-7-[3-(trifluoromethyl)-2-pyridinyl]-; 7-(3-(Trifluoromethyl)pyridin-2-yl)-4-chloroquinazoline
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-7-[3-(Trifluoromethyl)Pyridin-2-Yl]Quinazoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (NMR, IR), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.