Description

8-Chloro-6-(Trifluoromethyl)[1,2,4]Triazolo[4,3-A]Pyridine-3-Thiol is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a fused triazolopyridine core with chloro, trifluoromethyl, and thiol substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients. Its unique structure facilitates the development of compounds with potential bioactivity, making it essential for modern drug discovery and crop protection programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets, anti-infectives, and oncology research.
• Agrochemical Active Ingredient Development: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the triazolopyridine scaffold.
• Material Science Research: Acts as a building block for advanced organic materials, such as ligands for catalysts or components in organic electronic devices.
• Chemical Biology & Proteomics: Utilized as a reactive handle or tagging agent in probe development for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	8-Chloro-6-(Trifluoromethyl)[1,2,4]Triazolo[4,3-A]Pyridine-3-Thiol
CAS No.	571917-27-6
Molecular Formula	C7H2ClF3N3S
Molecular Weight	263.62 g/mol
Synonyms	8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-thiol; 8-Chloro-6-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-3-thiol; 8-Chloro-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyridine-3-thiol; 3-Mercapto-8-chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine; CAS 571917-27-6
EINECS	Contact for details

Quality Control

Our production of 8-Chloro-6-(Trifluoromethyl)[1,2,4]Triazolo[4,3-A]Pyridine-3-Thiol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with global regulatory frameworks, and our quality systems are designed to meet the exacting standards required for pharmaceutical and agrochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.