Description

2-Bromo-5-Ethynylpyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromine substituent and an ethynyl group, makes it an invaluable intermediate for constructing complex molecular architectures via cross-coupling and click chemistry reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalizing agent for creating conductive polymers, metal-organic frameworks (MOFs), and other advanced materials.
• Ligand & Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis and organometallic complexes.
• Chemical Biology & Bioconjugation: The ethynyl group enables efficient bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for probe and drug delivery system development.
• Organic Electronic Materials: A building block for electron-transport materials and emissive layers in OLED (Organic Light-Emitting Diode) research.

Basic Information

Product Name	2-Bromo-5-Ethynylpyridine
CAS No.	569672-28-2
Molecular Formula	C7H4BrN
Molecular Weight	182.02 g/mol
Synonyms	5-Ethynyl-2-bromopyridine; 2-Bromo-5-ethynylpyridine; Pyridine, 2-bromo-5-ethynyl-; 5-(Bromomethyl)pyridin-2-amine (isomer); 2-Bromo-5-ethynyl-pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Ethynylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.