Description

Cyclopropa[4,5]Cyclopenta[1,2-B]Pyridin-2(1H)-One, 5,5A,6,6A-Tetrahydro-6,6-Dimethyl-, (5Ar,6As)- (9Ci) is a high-purity, advanced pharmaceutical intermediate with the CAS number 561319-49-1. This complex heterocyclic compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel small-molecule drugs.
• Organic Synthesis Building Block: Used in complex multi-step organic syntheses to construct intricate molecular frameworks.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for methodological development and the study of heterocyclic chemistry.

Basic Information

Item	Details
Product Name	Cyclopropa[4,5]Cyclopenta[1,2-B]Pyridin-2(1H)-One, 5,5A,6,6A-Tetrahydro-6,6-Dimethyl-, (5Ar,6As)- (9Ci)
CAS No.	561319-49-1
Molecular Formula	C12H16N2O
Molecular Weight	204.27 g/mol
Synonyms	(5aR,6aS)-5,5a,6,6a-Tetrahydro-6,6-dimethylcyclopropa[4,5]cyclopenta[1,2-b]pyridin-2(1H)-one; 561319-49-1; Cyclopropacyclopentapyridinone derivative; 6,6-Dimethyl-5,5a,6,6a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-b]pyridin-2-one; (5aR,6aS)-rel-5,5a,6,6a-Tetrahydro-6,6-dimethylcyclopropa[4,5]cyclopenta[1,2-b]pyridin-2(1H)-one
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure consistency and purity for sensitive pharmaceutical R&D applications. Our rigorous analytical protocols include HPLC, GC, NMR, and MS to verify identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.