Description

3-Trifluoromethoxy-n-(Trimethylsilyl)Aniline is a high-value organosilicon intermediate featuring a unique trifluoromethoxy-aniline scaffold protected by a trimethylsilyl (TMS) group. This compound is critical for introducing both fluorine and silicon functionalities into target molecules, significantly altering their electronic properties, lipophilicity, and metabolic stability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for the synthesis of novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent for silicon-based polymers, liquid crystals, and organic semiconductors.
• Cross-Coupling Reactions: The TMS-protected aniline acts as a versatile reagent in palladium-catalyzed cross-coupling for constructing complex aromatic systems.
• Fluorine Chemistry Research: Essential for studying structure-activity relationships (SAR) in medicinal chemistry by introducing the trifluoromethoxy pharmacophore.
• Protecting Group Strategy: The TMS group allows for selective reactions on other parts of the molecule, which can be later deprotected under mild conditions.

Basic Information

Item	Details
Product Name	3-Trifluoromethoxy-n-(Trimethylsilyl)Aniline
CAS No.	561304-47-0
Molecular Formula	C10H14F3NOSi
Molecular Weight	249.31 g/mol
Synonyms	N-(Trimethylsilyl)-3-(trifluoromethoxy)aniline; 3-(Trifluoromethoxy)-N-(trimethylsilyl)benzenamine; 3-Trifluoromethoxy-N-trimethylsilylaniline; Aniline, 3-(trifluoromethoxy)-N-(trimethylsilyl)-; TMS-3-Trifluoromethoxyaniline; N-TMS-3-trifluoromethoxyaniline; 3-(Trifluoromethoxy)phenyl(trimethylsilyl)amine
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethoxy-n-(Trimethylsilyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.