Description

[2-(2,2,2-Trifluoroethoxy)Pyridin-4-Yl]Methanamine is a high-purity, specialized organic building block featuring a pyridine core substituted with a trifluoroethoxy group and an aminomethyl functionality. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical compounds and agrochemicals, where its unique fluorine-containing moiety can significantly alter biological activity and metabolic stability. It is primarily sought by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly in areas like kinase inhibitors, central nervous system (CNS) agents, and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoroethoxy group can enhance lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated pyridine derivative.

Basic Information

Product Name	[2-(2,2,2-Trifluoroethoxy)Pyridin-4-Yl]Methanamine
CAS No.	561297-93-6
Molecular Formula	C8H9F3N2O
Molecular Weight	206.17 g/mol
Synonyms	4-(Aminomethyl)-2-(2,2,2-trifluoroethoxy)pyridine; 1-[2-(2,2,2-Trifluoroethoxy)pyridin-4-yl]methanamine; 2-(2,2,2-Trifluoroethoxy)-4-pyridinemethanamine; (2-(2,2,2-Trifluoroethoxy)pyridin-4-yl)methanamine; 4-(Aminomethyl)-2-(trifluoroethoxy)pyridine; 2-(Trifluoroethoxy)-4-pyridinemethanamine
EINECS	Contact for details

Quality Control

Our [2-(2,2,2-Trifluoroethoxy)Pyridin-4-Yl]Methanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay purity, impurity profile, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.