Description

[2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl]-Carbamic Acid 9H-Fluoren-9-Ylmethyl Ester is a specialized, high-purity chemical building block designed for advanced organic synthesis. This compound matters for its role as a key protected intermediate, enabling the controlled introduction of functionalized polyethylene glycol (PEG) linkers in complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel drug conjugates, bioconjugation strategies, and advanced materials science.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring PEGylated linkers to enhance solubility, stability, or pharmacokinetic profiles.
• Peptide & Protein Conjugation: Used to introduce hydrophilic, flexible spacer arms during the chemical modification of peptides, proteins, and antibodies for therapeutic and diagnostic applications.
• Prodrug Synthesis: Serves as a key component in constructing prodrugs where a cleavable linker is required for targeted drug release.
• Polymer Chemistry: Acts as a functional monomer or chain extender in the creation of specialized polymers with tailored biocompatibility and degradation properties.
• Bioconjugation Reagent: Employed in the development of diagnostic assays, imaging probes, and targeted therapeutics that require stable, defined linkages between biomolecules and other entities.
• Research & Development: Essential for academic and industrial R&D exploring new synthetic methodologies, novel drug delivery systems, and advanced biomaterials.

Basic Information

Product Name	[2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl]-Carbamic Acid 9H-Fluoren-9-Ylmethyl Ester
CAS No.	560088-66-6
Molecular Formula	C22H27NO6
Molecular Weight	401.45 g/mol
Synonyms	Fmoc-NH-PEG3-OH; Fmoc-8-amino-3,6-dioxaoctanoic acid; N-(9-Fluorenylmethoxycarbonyl)-8-amino-3,6-dioxaoctanoic acid; Fmoc-N-amido-PEG3-acid; 2-[2-(2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]ethoxy)ethoxy]ethanol; Fmoc-PEG3-acid; N-α-Fmoc-8-amino-3,6-dioxaoctanoic Acid; Fmoc-AEEA-AEEA-OH
EINECS	Contact for details

Quality Control

Our [2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl]-Carbamic Acid 9H-Fluoren-9-Ylmethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.