Description

Volociximab is a high-purity, research-grade monoclonal antibody targeting α5β1 integrin. This compound is critical for advanced biomedical research and development, particularly in the study of angiogenesis and related therapeutic pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oncology and ophthalmology drug discovery.

Application

• Biomedical Research: A key reagent for in vitro and in vivo studies investigating the role of α5β1 integrin in tumor angiogenesis and metastasis.
• Therapeutic Development: Serves as a reference standard and a lead candidate in the development of anti-angiogenic and anti-cancer biologics.
• Mechanistic Studies: Used to block α5β1 integrin function to elucidate signaling pathways in cell adhesion, migration, and survival.
• Preclinical Evaluation: Essential for pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in animal models of cancer and eye diseases.
• Assay Development: Employed as a critical component in the development and validation of cell-based and biochemical assays for drug screening.
• Quality Control Reference: Acts as a purity and activity reference standard for the quality control of related biopharmaceutical products.

Basic Information

Product Name	Volociximab
CAS No.	558480-40-3
Molecular Formula	Contact for details
Molecular Weight	Approx. 150 kDa (Monoclonal Antibody)
Synonyms	M200; Anti-Integrin α-5 β-1 Recombinant Antibody; Anti-α5β1 Integrin Monoclonal Antibody; Volociximab (USAN); Recombinant Humanized Monoclonal Antibody M200; Anti-Fibronectin Receptor Antibody
EINECS	Contact for details

Quality Control

Our Volociximab is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is rigorously tested for purity, identity, potency, and sterility. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity by SEC-HPLC, endotoxin levels, binding affinity, and biological activity is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SEC-HPLC)	Corresponds to reference standard
Purity (SEC-HPLC)	≥ 95% (Monomer)
Protein Content (UV Absorbance)	≥ 1.0 mg/vial
Endotoxin	< 1.0 EU/mg
Biological Activity (Cell Binding)	Confirmed
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.