Description

2-((Trimethylsilyl)Ethynyl)Pyridin-3-Ol is a specialized organosilicon building block featuring a pyridine core functionalized with a trimethylsilyl-protected ethynyl group. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new crop protection agents and herbicides.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers and silicon-based hybrid materials.
• Ligand Synthesis for Catalysis: Employed to create sophisticated ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Academic & Industrial R&D: A versatile reagent for method development and exploratory synthesis in both academic and corporate research laboratories.

Basic Information

Product Name	2-((Trimethylsilyl)Ethynyl)Pyridin-3-Ol
CAS No.	556832-92-9
Molecular Formula	C10H13NOSi
Molecular Weight	191.31 g/mol
Synonyms	3-Hydroxy-2-((trimethylsilyl)ethynyl)pyridine; 2-[(Trimethylsilyl)ethynyl]pyridin-3-ol; 3-Pyridinol, 2-[(trimethylsilyl)ethynyl]-; 2-(Trimethylsilylethynyl)-3-hydroxypyridine; 2-(Trimethylsilylethynyl)pyridin-3-ol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed to confirm identity, purity, and consistency. We adhere to strict in-process controls and final release specifications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.