Description

Methyl 4-Bromo-2-(Difluoromethoxy)Benzoate is a high-purity, synthetically valuable organic intermediate. This compound is specifically engineered for advanced pharmaceutical and agrochemical research and development, where precise molecular architecture is critical. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life sciences industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the difluoromethoxy and bromo substituents for enhanced bioactivity and stability.
• Liquid Crystal & OLED Material Research: Serves as a precursor for the development of specialty chemicals used in electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo aryl group makes it an excellent substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, to create complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs) developing proprietary compounds.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and tags for studying biological systems and drug-target interactions.

Basic Information

Product Name	Methyl 4-Bromo-2-(Difluoromethoxy)Benzoate
CAS No.	553672-24-5
Molecular Formula	C9H7BrF2O3
Molecular Weight	281.05 g/mol
Synonyms	Benzoic acid, 4-bromo-2-(difluoromethoxy)-, methyl ester; Methyl 4-bromo-2-(difluoromethoxy)benzoate; 4-Bromo-2-(difluoromethoxy)benzoic acid methyl ester; 2-(Difluoromethoxy)-4-bromobenzoic acid methyl ester; Methyl 4-bromo-2-difluoromethoxybenzoate; CAS 553672-24-5
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-2-(Difluoromethoxy)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.