Description

Benzyl cis-3-Hydroxycyclobutanecarboxylate is a specialized chiral building block featuring both a benzyl ester and a hydroxyl group on a cyclobutane ring. This compound matters as a high-value intermediate for the synthesis of complex pharmaceutical molecules and advanced materials, offering precise stereochemical control. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the cis-cyclobutane scaffold imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for producing high-value, complex organic molecules.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and process development.

Basic Information

Product Name	Benzyl cis-3-Hydroxycyclobutanecarboxylate
CAS No.	552849-32-8
Molecular Formula	C12H14O3
Molecular Weight	206.24 g/mol
Synonyms	Benzyl (1S,3R)-3-Hydroxycyclobutanecarboxylate; cis-3-Hydroxycyclobutanecarboxylic Acid Benzyl Ester; (1S,3R)-3-Hydroxycyclobutanecarboxylic Acid Phenylmethyl Ester; Benzyl 3-Hydroxycyclobutanecarboxylate (cis-); Cyclobutanecarboxylic acid, 3-hydroxy-, benzyl ester, cis-; (cis)-Benzyl 3-hydroxycyclobutanecarboxylate; Phenylmethyl cis-3-hydroxycyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our Benzyl cis-3-Hydroxycyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistent enantiomeric excess. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.