Description

Cyclopentaneacetic Acid, 1-Ethynyl-2,3-Dihydroxy-, Ethyl Ester, (1S)- (9Ci) is a high-purity, chiral synthetic intermediate of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring a cyclopentane ring, ethynyl group, and multiple hydroxyl functionalities, makes it a valuable building block for constructing complex, stereochemically defined molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or reagent in catalytic asymmetric reactions to introduce specific stereocenters.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and develop proprietary compound libraries.
• Fine Chemical Production: Acts as a building block for the manufacture of specialty chemicals, flavors, fragrances, and advanced materials requiring high stereochemical purity.
• Academic & Contract Research: Used in university and CRO (Contract Research Organization) laboratories for methodological development and exploratory synthesis projects.

Basic Information

Product Name	Cyclopentaneacetic Acid, 1-Ethynyl-2,3-Dihydroxy-, Ethyl Ester, (1S)- (9Ci)
CAS No.	545363-19-7
Molecular Formula	C11H14O4
Molecular Weight	210.23 g/mol
Synonyms	(1S)-1-Ethynyl-2,3-dihydroxycyclopentaneacetic acid ethyl ester; Ethyl (1S)-1-ethynyl-2,3-dihydroxycyclopentaneacetate; (1S)-1-Ethynyl-2,3-dihydroxycyclopentylacetic acid ethyl ester; 545363-19-7; (S)-Ethyl 1-ethynyl-2,3-dihydroxycyclopentaneacetate; Cyclopentaneacetic acid, 1-ethynyl-2,3-dihydroxy-, ethyl ester, (1S)-; (1S)-1-Ethynyl-2,3-dihydroxycyclopentan-1-ylacetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Cyclopentaneacetic Acid, 1-Ethynyl-2,3-Dihydroxy-, Ethyl Ester, (1S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid or colorless to pale yellow liquid/oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (enantiomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.