Description

Iguratimod is a small molecule immunomodulatory agent with potent anti-inflammatory and disease-modifying properties. This compound is of significant interest for its targeted mechanism of action, which involves the selective inhibition of nuclear factor-kappa B (NF-κB) signaling and cytokine production. It serves as a critical active pharmaceutical ingredient (API) and reference standard for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on autoimmune and inflammatory disorders.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of prescription medications for autoimmune diseases.
• Rheumatoid Arthritis (RA) Treatment: Core therapeutic application in the development of novel disease-modifying antirheumatic drugs (DMARDs).
• Biomedical Research: Used as a selective NF-κB pathway inhibitor in immunological, inflammatory, and oncological research studies.
• Reference Standard: Serves as a high-purity calibrant in analytical laboratories for quality control (QC) and method development (HPLC, LC-MS).
• Preclinical & Clinical Development: Essential for pharmacokinetic, pharmacodynamic, and toxicology studies during drug development phases.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for commercial manufacturing.

Basic Information

Product Name	Iguratimod
CAS No.	544482-14-6
Molecular Formula	C₁₉H₁₅N₃O₄S₂
Molecular Weight	413.47 g/mol
Synonyms	T-614; 3-Formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one; 3-(Formylamino)-7-[(methylsulfonyl)amino]-6-phenoxy-4H-1-benzopyran-4-one; 3-FA-7-MSA-6-Ph-4H-1-BP-4-one; Iguratimodum; T 614; T614
EINECS	Contact for details

Quality Control

Our Iguratimod is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by spectroscopic methods. We provide full traceability and support regulatory filings with detailed Certificates of Analysis (COA) that meet the stringent requirements for pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.