Description

Apilimod is a potent and selective small-molecule inhibitor of the phosphoinositide 3-kinase delta isoform (PI3Kδ). This compound is a critical research tool for investigating the role of PI3Kδ signaling in immune cell function and inflammatory pathways. It is primarily utilized by pharmaceutical researchers and biotech companies engaged in drug discovery and development for autoimmune diseases, inflammatory disorders, and oncology. The high-purity grade of Apilimod CAS NO 541550-19-0 ensures reliable and reproducible results in preclinical studies.

Application

• Biochemical Research: Used as a selective probe to study PI3Kδ-mediated signaling cascades in cellular models.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel immunomodulatory and anti-inflammatory therapeutics.
• Inflammatory Disease Models: Applied in vitro and in vivo to validate PI3Kδ as a therapeutic target for conditions like rheumatoid arthritis, lupus, and asthma.
• Oncology Research: Investigated for its potential role in modulating the tumor microenvironment and in hematological malignancies where PI3Kδ is implicated.
• Cell Signaling Studies: Essential for elucidating the specific functions of PI3Kδ in B-cells, T-cells, and mast cells.

Basic Information

Product Name	Apilimod
CAS No.	541550-19-0
Molecular Formula	C₂₃H₂₅N₅O₂
Molecular Weight	403.48 g/mol
Synonyms	Apilimod; LAM-002A; 5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; PIK-75 analogue; PI3Kδ inhibitor; Phosphoinositide 3-kinase delta inhibitor; UNII-8V71L1X0S5
EINECS	Contact for details

Quality Control

Our Apilimod is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.