Description

(E)-Ethyl 2-Cyano-3-(3,5-Difluorophenylamino)Acrylate CAS NO 541505-10-6 is a high-purity, specialized acrylate derivative featuring a cyano group and a difluorophenylamino moiety. This compound is a critical advanced intermediate for synthesizing complex organic molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for research and development chemists and process engineers working on novel active ingredients, offering a versatile building block for constructing heterocyclic systems and functionalized scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting kinase inhibition and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its fluorinated aromatic structure for enhanced bioactivity and environmental stability.
• Organic Electronics Research: Serves as a building block for electron-deficient materials in the development of organic semiconductors and non-linear optical (NLO) materials.
• Dye and Pigment Chemistry: Acts as an intermediate for creating specialized fluorinated dyes and functional colorants with unique light-absorption properties.
• Academic & Industrial R&D: Employed in methodological studies and process chemistry for constructing complex molecular architectures via condensation and cyclization reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules at various scales.

Basic Information

Product Name	(E)-Ethyl 2-Cyano-3-(3,5-Difluorophenylamino)Acrylate
CAS No.	541505-10-6
Molecular Formula	C12H10F2N2O2
Molecular Weight	252.22 g/mol
Synonyms	Ethyl (2E)-2-cyano-3-[(3,5-difluorophenyl)amino]prop-2-enoate; 2-Propenoic acid, 2-cyano-3-[(3,5-difluorophenyl)amino]-, ethyl ester, (2E)-; (E)-Ethyl 2-cyano-3-(3,5-difluoroanilino)acrylate; Ethyl (E)-2-cyano-3-(3,5-difluorophenylamino)acrylate; 3-(3,5-Difluorophenylamino)-2-cyano-acrylic acid ethyl ester; Acrylic acid derivative 541505-10-6; 2-Cyano-3-(3,5-difluoroanilino)acrylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 2-Cyano-3-(3,5-Difluorophenylamino)Acrylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP and ISO compliant production for pharmaceutical applications, and material can be supplied to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.