Description

Methyl G-(Boc-Amino)-B-Oxo-Benzenepentanoate CAS NO 537712-55-3 is a high-purity, protected amino acid derivative primarily used as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for constructing complex peptide mimetics and other biologically active molecules, offering precise control over molecular architecture. It is a vital building block for pharmaceutical R&D, particularly in the development of protease inhibitors, novel APIs, and other therapeutic agents requiring specific stereochemistry and functional group protection.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and peptide-based drugs.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting various proteolytic enzymes.
• Peptidomimetic Synthesis: Essential for creating stable peptide analogs with enhanced metabolic stability and bioavailability.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold in drug discovery programs for structure-activity relationship (SAR) studies.
• Custom Peptide Synthesis: Employed in the solid-phase and solution-phase synthesis of complex, non-natural peptides for research.
• Bioconjugation & Linker Chemistry: Utilized in the design of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.

Basic Information

Item	Details
Product Name	Methyl G-(Boc-Amino)-B-Oxo-Benzenepentanoate
CAS No.	537712-55-3
Molecular Formula	C17H23NO6
Molecular Weight	337.37 g/mol
Synonyms	Methyl (2S)-2-[(tert-Butoxycarbonyl)amino]-5-oxo-5-phenylpentanoate; (S)-Methyl 2-((tert-butoxycarbonyl)amino)-5-oxo-5-phenylpentanoate; Boc-Phe(4-oxo)-OMe; Methyl 2-[(tert-Butoxycarbonyl)amino]-5-oxo-5-phenylpentanoate; 5-Oxo-5-phenyl-N-Boc-norvaline methyl ester; N-Boc-4-oxo-L-homophenylalanine methyl ester; A protected 4-oxo-L-homophenylalanine derivative
EINECS	Contact for details

Quality Control

Our Methyl G-(Boc-Amino)-B-Oxo-Benzenepentanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.