Description

Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 2-Propynyl Ester (9Ci) is a specialized Boc-protected amino acid derivative featuring a propargyl ester moiety. This compound is a crucial building block in modern organic synthesis, particularly valued for its dual functionality that enables selective chemical transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, bioconjugates, and other bioactive molecules. The product is supplied to the global market with a focus on consistent purity and reliable supply chain integrity.

Application

• Peptide Synthesis: Serves as a protected glycine derivative for the solid-phase and solution-phase synthesis of complex peptides, where the Boc group provides orthogonal protection.
• Bioconjugation & Click Chemistry: The propargyl ester group acts as a handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient labeling and conjugation of biomolecules.
• Pharmaceutical Intermediates: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates requiring specific glycine modifications.
• Chemical Biology Probes: Used in the design and synthesis of activity-based probes and molecular tools for studying enzymatic activity and protein function.
• Material Science: Incorporated into novel polymers and functional materials where amino acid-based monomers are required to impart specific properties.
• Agrochemical Research: Employed as an intermediate in the research and development of new crop protection agents and plant growth regulators.

Basic Information

Product Name	Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 2-Propynyl Ester (9Ci)
CAS No.	537710-06-8
Molecular Formula	C10H15NO4
Molecular Weight	213.23 g/mol
Synonyms	Boc-Glycine propargyl ester; N-(tert-Butoxycarbonyl)glycine 2-propynyl ester; Propargyl N-Boc-glycinate; N-Boc-glycine propargyl ester; 2-Propynyl N-[(1,1-dimethylethoxy)carbonyl]glycinate; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-propyn-1-yl ester; Boc-Gly-O-propargyl; tert-Butyloxycarbonylglycine propargyl ester
EINECS	Contact for details

Quality Control

Our production of Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 2-Propynyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.