Description

[Difluoro(Phenylsulfonyl)Methyl]Trimethyl-Silane is a specialized organosilicon reagent featuring a difluoromethyl sulfone group. This compound matters as a versatile building block for introducing the difluoromethylsulfonyl moiety, a valuable functional group in medicinal chemistry and materials science. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel bioactive molecules and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates containing the difluoromethyl sulfone pharmacophore.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides with enhanced properties.
• Material Science: Serves as a precursor for modifying polymer surfaces or creating specialty monomers with specific electronic characteristics.
• Cross-Coupling Reactions: Acts as an electrophilic reagent in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Fluorine Chemistry Research: A valuable tool for academic and industrial research exploring new methodologies in organofluorine chemistry.
• Ligand and Catalyst Development: Potential use in the synthesis of novel ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	[Difluoro(Phenylsulfonyl)Methyl]Trimethyl-Silane
CAS No.	536975-50-5
Molecular Formula	C10H14F2O2SSi
Molecular Weight	264.37 g/mol
Synonyms	Trimethyl([(phenylsulfonyl)difluoromethyl]silane; (Phenylsulfonyl)difluoromethyltrimethylsilane; α,α-Difluoro-α-(trimethylsilyl)benzenemethanesulfonate; (Difluoro(phenylsulfonyl)methyl)trimethylsilane; TMS-CF2SO2Ph
EINECS	Contact for details

Quality Control

Our [Difluoro(Phenylsulfonyl)Methyl]Trimethyl-Silane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.