Description

2-tert-Butoxycarbonylamino-4-(tert-Butyl-Diphenyl-Silanyloxy)-Butyric Acid Methyl Ester is a sophisticated, multi-functional protected amino acid derivative designed for advanced organic synthesis. This compound is a critical building block for the controlled assembly of complex peptides and other bioactive molecules, offering orthogonal protection strategies. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors. Its specific structure enables precise synthetic manipulations, making it invaluable for the development of novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Serves as a crucial building block for solid-phase and solution-phase peptide synthesis, where the tert-butoxycarbonyl (Boc) and tert-butyldiphenylsilyl (TBDPS) groups provide orthogonal protection.
• Chemical Biology Research: Used in the design and synthesis of peptide mimetics, probes, and labeled compounds for studying biological pathways and protein interactions.
• Process Development: Employed in scaling up synthetic routes for candidate drugs during preclinical and clinical development phases.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized, high-value fine chemicals for clients.

Basic Information

Product Name	2-tert-Butoxycarbonylamino-4-(tert-Butyl-Diphenyl-Silanyloxy)-Butyric Acid Methyl Ester
CAS No.	534602-91-0
Molecular Formula	C27H39NO5Si
Molecular Weight	485.70 g/mol
Synonyms	Boc-Asp(OtBu)-OH methyl ester (TBDPS protected); Methyl 2-((tert-butoxycarbonyl)amino)-4-((tert-butyldiphenylsilyl)oxy)butanoate; Boc-Asp(OtBu)-OMe (TBDPS); 2-(Boc-amino)-4-(tert-butyldiphenylsiloxy)butyric acid methyl ester; N-Boc-4-[(tert-butyldiphenylsilyl)oxy]-L-homoserine methyl ester (racemic/intermediate form); Protected Aspartic Acid Derivative Methyl Ester; CAS 534602-91-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under GMP-like conditions where required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.