Description

cis-Cyclobutane-1,3-Dicarboxylic Acid Mono-tert-Butyl Ester CAS NO 528560-20-5 is a high-purity, versatile chiral building block featuring a rigid cyclobutane ring system. This compound is valued for its unique stereochemistry and bifunctional nature, enabling precise molecular construction in advanced synthetic pathways. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cis-cyclobutane scaffold can impart specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored thermal and mechanical properties.
• Peptidomimetics and Conformationally Restricted Analogs: The constrained cyclobutane ring is instrumental in designing peptide mimics and rigid analogs for structure-activity relationship (SAR) studies.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients requiring specific chiral intermediates.

Basic Information

Product Name	cis-Cyclobutane-1,3-Dicarboxylic Acid Mono-tert-Butyl Ester
CAS No.	528560-20-5
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	1,3-cis-Cyclobutanedicarboxylic Acid Mono-tert-Butyl Ester; (1R,3S)-Cyclobutane-1,3-dicarboxylic Acid Mono-tert-Butyl Ester; (1S,3R)-Cyclobutane-1,3-dicarboxylic Acid Mono-tert-Butyl Ester; cis-1,3-Cyclobutanedicarboxylic Acid 1-tert-Butyl Ester; cis-3-(tert-Butoxycarbonyl)cyclobutane-1-carboxylic Acid; Mono-tert-butyl cis-cyclobutane-1,3-dicarboxylate; BOC-Cyclobutane-cis-1,3-dicarboxylic Acid Monoester
EINECS	Contact for details

Quality Control

Our cis-Cyclobutane-1,3-Dicarboxylic Acid Mono-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. We provide detailed Certificates of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic). Keep container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.